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CONCLUSIONS: These findings suggested that the variation in the gut microbiota dynamics could be considered as a possible complementary biomarker to understand the individualized responses within dietary interventions aimed at improving metabolic health in childhood. Further well-designed intervention study is needed to define these observational associations.

The allocation of finite cellular resources is a fundamental principle that dictates microbial metabolic strategies and gives rise to complex phenomena, such as overflow metabolism, characterized by the production of respiro-fermentative byproducts, including acetate, during rapid growth. While proteome-constrained models have successfully predicted overflow metabolism in Escherichia coli, they often overlook the distinct biophysical and energetic costs associated with protein localization. The...

CONCLUSIONS: We present a multi-omic atlas of healthy, diseased, and ex vivo-stimulated woodchuck liver. This work identified shared WHV-HBV pathological processes, reinforces the value of this preclinical model and provides a resource to advance HBV pathogenesis studies and therapeutic development.

Glioblastoma (GBM) is an aggressive brain cancer with a poor survival rate. Despite hundreds of clinical trials, there is no effective targeted therapy. Glioblastoma stem cells (GSCs) are an important GBM model system. In culture, these cells form spatial structures that share morphological aspects with their source tumors. We collected 17,000 phase-contrast images of 15 patient-derived GSC lines growing to confluence. We find that GSCs grow in characteristic multicellular patterns depending on...

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs and PAHs are toxic posing risks to wildlife and human health. While regular monitoring activities have been implemented in most Arctic countries, information from the Russian Arctic is still limited. This...

CONCLUSIONS: This study represents the largest and most comprehensive cohort of patients with DPLGG to date. While histopathology and tumor location were associated with hydrocephalus in this cohort, the dissemination pattern was not directly associated with hydrocephalus incidence but rather the timing of hydrocephalus diagnosis. Hydrocephalus does not impact survival in patients with DPLGG; however, it is associated with worse functional outcomes.

Recent advances in protein structure prediction have created high-confidence candidate structures for nearly every known protein-coding gene. At the same time, many software packages have been created to visualize protein structures, protein multiple sequence alignments (MSAs), and protein annotations. However, few software tools can highlight the direct relationship between nucleotide variation of protein-coding genes in genome space and the evolutionary and structural context of that variation...

The third Critical Assessment of Computational Hit-finding Experiments (CACHE) challenged computational teams to identify chemically novel ligands targeting the macrodomain 1 of SARS-CoV-2 Nsp3, a promising coronavirus drug target. Twenty-three groups deployed diverse design strategies to collectively select 1739 ligand candidates. While over 85% of the designed molecules were chemically novel, the best experimentally confirmed hits were structurally similar to previously published compounds....

CONCLUSION: Students with and without anatomy backgrounds contributed to ODFs using a similar level of engagement but different social participatory roles. This work highlights the importance of supporting different peer-learning roles in anatomy ODFs.

Centralizing valuable community data and resources into a user-friendly interface and accessible repository has become essential for agricultural science; embracing Findable Accessible, Interoperable, and Reusable (FAIR) principles is now standard for effective databases. SorghumBase (https://www.sorghumbase.org) is a knowledgebase designed for the sorghum research community. The SorghumBase team curates genomic, transcriptomic, variation, and phenotypic information and aggregates community...

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