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B-cell lymphoma 6 (BCL6) is a transcriptional repressor protein central to the development and maintenance of germinal centers (GCs) during the humoral immune response. BCL6 is often deregulated in diffuse large B-cell lymphoma (DLBCL), a type of non-Hodgkin's lymphoma, and inhibition of the protein-protein interaction between BCL6 and corepressors has been implicated as a therapeutic strategy. Based on a previously identified small molecule binding site on the BCL6 BTB domain, we carried out a...

Dysregulation of the adaptive immune system is a key feature of aging and is associated with age-related chronic diseases and mortality. Here, we find that T cell aging, especially in the CD4 subset, is controlled by B cells. B cells contributed to the age-related reduction of naive CD4 T cells, their differentiation toward immunosenescent T cell subsets, and age-associated T cell receptor clonal restriction. Concurrently, mice lacking B cells displayed improvements in health span and life span....

Individuals with hereditary cancer syndromes are born with germline genetic variants that significantly increase their lifetime risk of developing multiple cancers. Cancer rates and overall mortality can be reduced with intensive surveillance to facilitate early cancer detection. However, participating in diagnostic imaging and endoscopy surveillance programs is often time-consuming, overwhelming, inconvenient, and anxiety-inducing. To improve this, multi-cancer early detection tests are being...

Accurate intrapartum biometry plays a crucial role in monitoring labor progression and preventing complications. However, its clinical application is limited by challenges such as the difficulty in identifying anatomical landmarks and the variability introduced by operator dependency. To overcome these challenges, the Intrapartum Ultrasound Grand Challenge (IUGC) 2025, in collaboration with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), was...

As DNA sequencing technologies improve, it is becoming easier to sequence and assemble new genomes from non-model organisms. However, before a newly assembled genome sequence can be used as a reference, it must be annotated with genes and other features. This can be conducted by individual laboratories using publicly available software. Modern genome annotations integrate gene predictions from the assembled DNA sequence with gene homology information from other high-quality reference genomes and...

CONCLUSIONS AND RELEVANCE: In this cohort study, young adults with 4Cs had longer acute care medical hospitalizations, accounting for 10.7% of all young adult hospital bed-days, and more rehospitalizations than other young adults. The results suggest that this population should be prioritized for targeted measures to reduce inpatient stays and improve care. The Charlson Comorbidity Index may be of limited utility for capturing comorbidities in this population.

Streptococcus dysgalactiae subsp. equisimilis (SDSE) has historically been recognized as a human pathogen, yet β-hemolytic streptococci consistent with SDSE have been documented in pigs for nearly a century. To investigate the population structure of porcine SDSE and the phylogenetic relationships between swine and human strains, we characterized 41 isolates recovered from diseased pigs in Quebec, Canada (2019-2022). Infected animals spanned all major production stages and frequently presented...

CONCLUSIONS: These findings suggested that the variation in the gut microbiota dynamics could be considered as a possible complementary biomarker to understand the individualized responses within dietary interventions aimed at improving metabolic health in childhood. Further well-designed intervention study is needed to define these observational associations.

The allocation of finite cellular resources is a fundamental principle that dictates microbial metabolic strategies and gives rise to complex phenomena, such as overflow metabolism, characterized by the production of respiro-fermentative by-products, including acetate, during rapid growth. Although proteome-constrained models have successfully predicted overflow metabolism in Escherichia coli, they often overlook the distinct biophysical and energetic costs associated with protein localization....

CONCLUSIONS: We present a multi-omic atlas of healthy, diseased, and ex vivo-stimulated woodchuck liver. This work identified shared WHV-HBV pathological processes, reinforces the value of this preclinical model and provides a resource to advance HBV pathogenesis studies and therapeutic development.