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Unlike the well-known charge-carrier kinetics in traditional photocatalysis, a knowledge gap remains regarding the photo-kinetic effects in heterogeneous photothermal catalysis. Conventionally, light is mainly regarded as a source of charge carriers and localized heating, yet how these light-induced effects alter intrinsic reaction kinetics, particularly the rate-determining step (RDS), remains unclear. Here, we provide direct kinetic evidence that illumination tunes the RDS in an archetypal...

MOTIVATION: The canonical vocabulary of twenty amino acids limits the chemical space available to proteins and peptides. Expanding this vocabulary to hundreds of non-canonical amino acids (ncAAs) allows the engineering of proteins with novel function and activity, and is of particular interest for therapeutic peptides such as macrocycles, where ncAAs can improve proteolytic stability, membrane permeability and immunogenicity. However, existing structure-based design tools either cannot model...

This Letter reports on the first evidence of inclusive Higgs-boson production at high transverse momentum in the bb[over ¯] final state, reconstructed in a single large-radius jet. The results are based on proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider at a center-of-mass energies of 13 and 13.6 TeV, corresponding to a total integrated luminosity of 301 fb^{-1}. The study profits from the large background suppression provided by the use of a new...

Compound-specific isotope analysis (CSIA) is widely used to verify in situ biodegradation of organic contaminants. Chloroanilines are persistent groundwater pollutants known to undergo reductive dechlorination under environmental conditions, yet their isotope fractionation remains unclear. This study reports multi-element isotopic fractionation (ε) associated with reductive dechlorination of 2,3-dichloroaniline (2,3-DCA) and 2-chloroaniline (2-CA) using a Dehalobacter-dominated enrichment...

Adequately powered analyses in precision oncology often require combining cohorts across institutions. Yet integration is constrained by the least granular source and may become infeasible when data elements are too heterogeneous to harmonize and map to a common data model. This challenge is acute in multi-institutional precision oncology research, where real-world evidence requires harmonized clinico-omic data integration. Existing models often lack sufficient treatment patterns, outcomes, and...

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Advances in sequencing technology have enabled population-level Whole Genome Sequencing (WGS) efforts to be undertaken in many countries. Often, this requires collaboration across a distributed network of sequencing centres to allow efficient use of existing resources. Previously we tested the robustness of short-read sequencing technology and analysis pipelines across three established sequencing centres located in Montreal, Toronto, and Vancouver, constituting CGEn, Canada's national platform...

BACKGROUND: Sex differences in major depressive disorder (MDD) are well documented, but it remains unclear whether sex-related variation in peripheral endocannabinoid system (ECS)-related biomarkers is detectable in MDD.

Cells undergoing division mount a unique response to DNA damage that ensures accurate chromosome segregation. The CIP2A-TOPBP1 complex has emerged as an important mitotic genome maintenance factor, but its function remains unclear. Here, we report that DDIAS is a DNA-binding effector of the CIP2A pathway in human cells. DDIAS physically interacts with TOPBP1, and its inactivation causes synthetic lethality with BRCA1 and BRCA2 deficiency. Homologous recombination (HR)-deficient tumors upregulate...

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CONCLUSIONS: This benchmark demonstrated the utility of CoW segmentation algorithms for some downstream clinical applications with explainability. The annotated datasets and top-performing algorithms are published alongside this benchmark to foster methodological advances and clinical tool development. (Funded by the Digitalization Initiative of the Zurich Higher Education Institutions and the Helmut Horten Foundation.).

INTRODUCTION: Subclinical cardiovascular remodeling may impair cerebral hemodynamics and contribute to dementia, but the perfusion features linking subclinical cardiovascular dysfunction to cerebrovascular injury remain unclear.

MYC-driven (MYC^(+)) cancers are highly aggressive and often fatal. MYC dysregulation is a key event in these cancers, yet MYC overexpression alone is often insufficient to initiate or sustain tumorigenesis. Plasmocytoma variant translocation 1 (PVT1), a long noncoding RNA (lncRNA) adjacent to MYC on chromosome 8q24, is frequently co-amplified with MYC in many of these cancers. Our prior work showed that PVT1 potentiates MYC function, although the underlying mechanism has remained unclear. Here...

Genomic rearrangements can drive cancer through mechanisms that extend beyond classical oncogenic fusions such as BCR-ABL A substantial fraction of these events involve long noncoding RNAs (lncRNAs), yet their functional impact on tumorigenesis has remained largely opaque. The lncRNA plasmacytoma variant translocation 1 (PVT1), positioned adjacent to MYC at chromosome 8q24, is among the most frequently altered loci in MYC-driven (MYC^(+)) cancers. We recently showed that PVT1 translocations...

Condensed aromatic carbon (ConAC) is widely recognized as a chemically recalcitrant component of soil organic matter. However, its stock and potential transformation into dissolved condensed aromatic carbon (dConAC) in forest soils may be altered in response to environmental changes that alter forest litter production. Using three decades of detrital input and removal treatments in a temperate forest, we investigated bulk ConAC and dConAC in soil profiles with the benzene polycarboxylic acid...

The sharing of data generated by clinical genetic and genomic testing without explicit consent is important for timely diagnosis and treatment. While many jurisdictions permit the sharing of identifiable data for direct clinical care, institutional policies vary in how clearly they specify key elements, including when sharing is permitted, what data are covered, and what safeguards apply. Greater clarity around these elements may support responsible data sharing while balancing timely care with...

Heterozygous loss-of-function variants in Neurabin I (PPP1R9A), responsible for encoding a cytoskeletal scaffolding protein essential for synaptic plasticity, are recurrently associated with neurodevelopmental and neuropsychiatric disorders, yet their direct effects on human neuronal maturation remain unclear. Here, we establish the first comprehensive human mechanistic model of PPP1R9A haploinsufficiency using an isogenic CRISPR/Cas9-engineered iPSC system differentiated into cortical neurons...

CONCLUSIONS: Children and adolescents develop recurrent AVMs at a higher rate than adult patients despite angiographic cure after initial resection. On multivariable analysis, deep venous drainage was independently associated with recurrence. Further work can help elucidate clinical and radiographic predictors of disease recurrence.

CONCLUSIONS: AMR and graft loss following kidney transplantation were defined by compartment-specific disruptions in complement and mitochondrial proteins.

CONCLUSION: The mis-localization and altered post-translational modification of p.(Ala2Val) DKC1 provides functional evidence to clinical laboratories to reclassify p.(Ala2Val) variant as "pathogenic" as per American College of Medical Genetics (ACMG) variant interpretation guidelines.