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This Letter presents a measurement of prompt charged-particle production in proton-oxygen interactions at sqrt[s_{NN}]=9.62 TeV center-of-mass energy with the ATLAS detector, corresponding to 634 μb^{-1} of integrated luminosity. A total of 246×10^{6} selected events have at least one track with transverse momentum p_{T}>500 MeV and pseudorapidity |η|<2.5. The measured fiducial proton-oxygen cross section is σ_{fid.}^{pO}=396±6(exp.)±9(lumi.) mb and the extrapolated inelastic proton-air cross...

MOTIVATION: Dose-response metrics such as the half-maximal inhibitory concentration, high-dose-response, and slope are central to drug discovery, yet standard Levenberg-Marquardt fits often produce biased or unsupported values for incomplete curves and lack uncertainty measures. In practice, this forces experimenters to visually inspect each curve fit to judge its reliability, a tedious, subjective, and non-scalable process.

CONCLUSIONS: Patients with severe ACLF who underwent LT showed markedly better survival outcomes than those who were declined. Patients with five or six organ failures had high risk of post-LT death cautioning against routine LT in this population.

CONCLUSIONS AND RELEVANCE: Heart failure is a significant global public health burden, and the impact is likely to increase as populations age. However, most HF etiologies can be prevented by interventions that reduce exposure to modifiable risk factors, such as elevated blood pressure, excessive alcohol consumption, and tobacco use. Etiology- and location-specific estimates can provide necessary information for public health officials to determine how best to prioritize interventions to reduce...

Surface frustrated Lewis pairs (SFLPs) have been widely studied as active sites for light-assisted CO(2) hydrogenation, while most efforts have focused on cation engineering to tune the Lewis acidity of metal centers, leaving the Lewis-basic component less directly controlled. Here, we report an anion engineering strategy based on nitridation to prepare nitrogen-doped, non-stoichiometric spinel zinc gallium oxide catalysts for CO(2) hydrogenation to methanol. Nitrogen incorporation modifies the...

As machine learning (ML) becomes increasingly important in protein engineering, synthetic biology, and bioprocess optimisation, the lack of consistent, complete, and standardised experimental reporting remains a major barrier to building effective models. EXPERT (EXpression and Purification Experimental Reporting Template) defines a structured framework for capturing protein expression and purification data across the community, to increase reproducibility across laboratories and support...

Oral squamous cell carcinoma (OSCC) often arises from oral epithelial dysplasia (OED); however, the gene expression changes during OED progression and its microenvironment are not fully understood. This study used spatial transcriptomics to identify differentially expressed genes and microenvironmental alterations associated with malignant transformation of OED. A retrospective analysis of paired OSCC and OED samples was conducted at the Faculty of Dentistry, University of Toronto. A total of 24...

During the Drosophila maternal-to-zygotic transition, maternally deposited RNAs are cleared in a temporally controlled manner. The RNA-binding protein Smaug is a major regulator of maternal mRNA decay and its expression at both the RNA and protein level is limited to a narrow temporal window during the MZT. Here we show that the Pumilio RNA-binding protein promotes degradation of smaug mRNA at the end of the MZT through Pumilio-binding cis-elements in the smaug 3´ untranslated region, and that...

Cancer genomics and precision oncology are increasingly central to cancer care, but many health systems struggle to implement them equitably, effectively, and sustainably. This Commission defines the current global precision oncology landscape and analyses the scientific, structural, and health-system challenges shaping its delivery and impact. Findings indicate that access to cancer genomics and precision oncology remains profoundly unequal across and within countries, leaving millions of...

Cancer genomic data sharing is a core pillar of precision oncology, underpinning reproducibility, scalability, and equity. The ability to discover, access, integrate, interpret, and reuse cancer 'omics data is a key determinant of precision oncology's value and benefit at scale. This work has been conducted as part of The Lancet Oncology Commission on Cancer Genomics and Precision Oncology to examine the practical data architecture required to support cancer genomics in research, clinical care,...

The integration of copy number variant (CNV) workflows into genome sequencing (GS) analysis pipelines allows for the identification of CNVs implicated in disease. Here, we generated a novel resource of CNVs identified in the HostSeq population cohort from Canada, identified the prevalence of recurrent CNVs associated with neurodevelopmental disorders, and determined CNVs of potential clinical relevance for reproductive planning and personal disease risk. GS data and CNV calls were generated for...

Entanglement is a key property of quantum systems. In this Letter the first measurements of quantum entanglement between spins in pairs of Z bosons are reported, using proton-proton collision data from the Large Hadron Collider (LHC) at center-of-mass energies of 13 and 13.6 TeV, recorded with the ATLAS detector. Measurements of angular observables sensitive to ZZ^{*} spin-density-matrix elements in the H→ZZ^{*}→ℓ^{+}ℓ^{-}ℓ^{+}ℓ^{-} process yield coefficients C_{2,1,2,-1}=-0.71±0.45 and...

The microbial utilization of carbohydrates produces metabolic byproducts that are associated with health benefits, such as short-chain fatty acids (SCFAs). The rapid absorption of SCFAs by intestinal epithelial cells makes them challenging to study in vivo. Culturing methods address this limitation by providing controlled conditions that allow for monitoring substrate utilization and the production of fermentation byproducts. In this paper, we describe an easily implemented, cost-effective...

SUMMARY: FAIDR-Desi is a non-technical user interface for design of intrinsically disordered regions (IDRs) based on greedy optimization of sequence features (simple sequence statistics correlated with IDR function, including amino acid composition, residue patterning and short linear interaction motifs), using more features (127) than other IDR design approaches. FAIDR-Desi can be used to design synthetic IDR mimics to establish feature sufficiency for function, or to knock out features to show...

CONCLUSIONS: The findings support cortical myoclonus as a relatively common and clinically actionable movement disorder in 22q11.2DS. As for Parkinson's disease, the results provide preliminary evidence supporting the chromosome 22q11.2 microdeletion as a potential risk-conferring CNV for cortical myoclonus, adding to the genetic heterogeneity associated with this movement disorder.

CONCLUSIONS: PF ependymoma comprises two biologically and clinically distinct entities. Maximal safe resection and focal radiotherapy remain the backbone of treatment, but integrating molecular subgrouping, imaging biomarkers, and modern radiotherapeutic techniques into surgical and adjuvant planning offers the clearest path to improved outcomes, particularly for high-risk PFA tumors.

Next-generation sequencing has transformed diagnosis, prognosis, and treatment across rare disease, cancer, immunology, and infectious disease. As variant interpretation may evolve with emerging evidence, sharing genetic data is essential to improve diagnostic accuracy and advance genomic medicine. However, practical guidance for implementing clinical genetic data sharing remains limited. The Canadian College of Medical Geneticists (CCMG), therefore, developed national guidance to support...

The microbial degradation of synthetic polyesters such as polyethylene terephthalate (PET) is mediated by diverse α/β-hydrolases, many of which remain poorly characterized. In this study, we investigated SM0281, an uncharacterized α/β-hydrolase from the symbiotic legume-associated rhizobacterium Sinorhizobium meliloti. Sequence analysis revealed that SM0281 shares low similarity with known polyester-degrading enzymes. Biochemical characterization of purified SM0281 demonstrated that it is a...

CONCLUSIONS: This study will provide initial evidence on the feasibility and utility of wearable-based digital phenotyping in individuals receiving rTMS for TRD. Our findings will inform the design of future large-scale studies aimed at wearable-supported relapse prevention and precision monitoring in depression care.

Primitive hematopoietic stem cells (pHSCs) sustain lifelong hematopoiesis through tightly regulated transitions between quiescence and activation. Circadian oscillations influence hematopoiesis; however, the mechanisms coordinating metabolic state and stem cell function daily remain incompletely defined. Here, we show that circadian cues coordinated a program of mitochondrial remodeling, metabolic reprogramming, and structural adaptation in pHSCs. At night, peak melatonin levels were associated...